Anti-MICB antibodies are used in the immunodetection of the protein MHC class I polypeptide-related sequence B. In humans, the canonical protein has a reported length of 383 amino acid residues and a mass of 42.6 kDa. Its subcellular localization is in the cell membrane. Up to 3 different isoforms have been reported for this protein. It is reported to be widely expressed with the exception of the central nervous system where it is absent. A member of the MHC class I protein family, MICB is known to be involved with adaptive immune responses. Post-translational modifications have been described, including protein cleavage and glycosylation. The MICB gene has been associated with the disease, Rheumatoid arthritis. Synonyms for this target antigen include MHC class I antigen-related protein B, MHC class I chain-related protein B, MHC class I mic-B antigen, MHC class I-like molecule PERB11.2-IMX, stress inducible class I homolog, and PERB11.2.