Anti-Anoctamin 2 antibodies are used for the immunodetection of the protein encoded by the ANO2 gene. In humans, the canonical protein has a reported length of 1003 amino acid residues and a mass of 114 kDa. Its subcellular localization is in the cell membrane. Alternative splicing is reported to yield 2 different isoforms for this protein. It is a member of the Anoctamin protein family. Post-translational modifications have been described, including glycosylation.
The anoctamin 2 marker can be used to characterize Cerebral Cortex Neurons.* Other names for this target antigen include transmembrane protein 16B (eight membrane-spanning domains), and anoctamin 2, calcium activated chloride channel. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species. A number of Anoctamin 2 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4