Anti-SMCHD1 antibodies are used in the immunodetection of the protein structural maintenance of chromosomes flexible hinge domain containing 1. In humans, the canonical protein has a reported length of 2005 amino acid residues and a mass of 226.4 kDa. Its subcellular localization is in the chromosomes. Alternative splicing is reported to yield 3 different isoforms for this protein. A member of a the SMC protein family, SMCHD1 is reported to be a non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture (By similarity). Post-translational modifications have been described, including sumoylation. Synonyms for this target antigen include FSHD2, structural maintenance of chromosomes flexible hinge domain-containing protein 1, SMC hinge domain-containing protein 1, and BAMS.