Anti-ryanodine receptor 2 antibodies are used in the immunodetection of the protein encoded by the RYR2 gene. In humans, the canonical protein has a reported length of 4967 amino acid residues and a mass of 564.6 kDa. Alternative splicing is reported to yield 2 different isoforms for this protein. It is notably expressed in heart muscle. A member of the Ryanodine receptor (TC 1.A.3.1) protein family, it is reported to be a calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Post-translational modifications have been described, including phosphorylation. Other names for this target antigen include ARVD2, RyR, VACRDS, VTSIP, cardiac muscle ryanodine receptor-calcium release channel, and ARVC2.