Anti-R-spondin1 antibodies are used for the immunodetection of the protein encoded by the RSPO1 gene. In humans, the canonical protein has a reported length of 263 amino acid residues and a mass of 29 kDa. Its subcellular localization is in the nucleus and is secreted. Alternative splicing is reported to yield 3 different isoforms for this protein. It is found to be highly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen. A member of the R-spondin protein family, it is reported to be an activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Post-translational modifications have been described, including glycosylation. Other names for this target antigen include R-spondin homolog and roof plate-specific spondin-1. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Indicated applications for R-spondin1 antibodies listed below include ELISA, Western Blot, Immunofluorescence, and Immunohistochemistry.