Anti-SLC18A2 antibodies are used in the immunodetection of the protein solute carrier family 18 member A2. In humans, the canonical protein has a reported length of 514 amino acid residues and a mass of 55.7 kDa. Its subcellular localization is in the cytoplasmic vesicles. Up to 2 different isoforms have been reported for this protein. It is reported to be expressed in neuronal and neuroendocrine tissues. A member of the Vesicular transporter protein family, SLC18A2 is reported to be an electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Post-translational modifications have been described, including glycosylation.
The SLC18A2 marker can be used to identify Tissue Resident Mucosal Type Mast Cells and Connective Tissue Type Mast Cells.* Synonyms for this target antigen include SVAT, SVMT, VAT2, VMAT2, synaptic vesicular amine transporter, and PKDYS2. SLC18A2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4