HENMT1 encodes the human gene, HEN1 methyltransferase homolog 1 (Arabidopsis). It may also be known as: Small RNA 2'-O-methyltransferase; HEN1 methyltransferase homolog 1; Small RNA 2'-O-methyltransferase ; HEN1 methyltransferase homolog (Arabidopsis); C1orf59; HEN1. The encoded protein is an enzyme with an amino acid length of 393 and a mass of 44.5 kDa. Other isoforms may exist. HENMT1 is a member of the Methyltransferase superfamily, HEN1 family. Homologs of this gene exist in other organisms, including: Frog.