Anti-uroplakin 3A antibodies are used for the immunodetection of the protein encoded by the UPK3A gene. In humans, the canonical protein has a reported length of 287 amino acid residues and a mass of 30.7 kDa. Its subcellular localization is in the ER. Alternative splicing is reported to yield 2 different isoforms for this protein. It is notably expressed in ureter. A member of the Uroplakin-3 protein family, it is a known component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. Post-translational modifications have been described, including glycosylation.
The uroplakin 3A marker can be used to characterize Ureter Urothelium Superficial Cells and Bladder Urothelium Superficial Cells.* Other names for this target antigen include UPIII, UPIIIA, UPK3, uroplakin 3, uroplakin III, and UP3A. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species. A number of uroplakin 3A antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.
*HuBMAP Human Reference Atlas v1.4