Anti-ZFHX3 antibodies are used in the immunodetection of the protein zinc finger homeobox 3. In humans, the canonical protein has a reported length of 3703 amino acid residues and a mass of 404.4 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 2 different isoforms have been reported for this protein. ZFHX3 is a reported transcriptional regulator which can act as an activator or a repressor. Post-translational modifications have been described, including ubiquitination, sumoylation, protein cleavage and phosphorylation.
The ZFHX3 marker can be used to identify Midbrain Splatter Neurons, Brain Splatter Neurons, Ventral Excitatory Neurons, and Medial Excitatory Neurons.* Synonyms for this target antigen include ATBT, C16orf47, ZFH-3, ZNF927, zinc finger homeobox protein 3, and ATBF1. ZFHX3 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of ZFHX3 antibodies have been mentioned in research publications and have associated citations. Immunohistochemistry is a widely used application for these antibodies. ELISA, Western Blot, and Immunofluorescence are also common applications.
*HuBMAP Human Reference Atlas v1.4