Anti-tolloid like 1 antibodies are used for the immunodetection of the protein encoded by the TLL1 gene. In humans, the canonical protein has a reported length of 1013 amino acid residues and a mass of 114.7 kDa. It is known to be a secreted protein. Alternative splicing is reported to yield 2 different isoforms for this protein. It is noted to be involved in cell differentiation and skeletal system development. Post-translational modifications have been described, including glycosylation. The tolloid like 1 marker can be used to characterize Eccentric Medium Spiny Neurons.* Other names for this target antigen include ASD6 and TLL. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Western Blot is the most common application for the tolloid like 1 antibodies listed below. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4