Anti-thrombospondin 4 antibodies are used for the immunodetection of the protein encoded by the THBS4 gene. In humans, the canonical protein has a reported length of 961 amino acid residues and a mass of 105.9 kDa. Its subcellular localization is in the ER, extracellular matrix, and is secreted. A member of the Thrombospondin protein family, it is reported to be an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Post-translational modifications have been described, including glycosylation. Other names for this target antigen include TSP-4 and TSP4. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.