Anti-SRGN antibodies are used in the immunodetection of the protein serglycin. In humans, the canonical protein has a reported length of 158 amino acid residues and a mass of 17.7 kDa. Its subcellular localization is in the Golgi and cytoplasm. It is notably expressed in the skin, lymph node, lung, bone marrow, and appendix. A member of the Serglycin protein family, SRGN is reported to play a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Post-translational modifications have been described, including O-glycosylation. The SRGN marker can be used to identify Brain Microglia and Brain Vascular Non-Neuronal Cells.* Synonyms for this target antigen include PRG, PRG1, hematopoetic proteoglycan core peptide, hematopoetic proteoglycan core protein, hematopoietic proteoglycan core protein, and PPG. SRGN gene orthologs have been reported in the mouse, rat, bovine, zebrafish and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4