Anti-Sulfatase 1 antibodies are used for the immunodetection of the protein encoded by the SULF1 gene. In humans, the canonical protein has a reported length of 871 amino acid residues and a mass of 101 kDa. Its subcellular localization is in the ER, Golgi, and is secreted. It is reported to be expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine and colon. A member of the Sulfatase protein family, it is known to be involved with the apoptotic pathway and bone development. Post-translational modifications have been described, including glycosylation.
The sulfatase 1 marker can be used to characterize Deep-Layer Corticothalamic And 6B Neurons, Cerebral Cortex MGE Interneurons, Myofibroblasts, and Dorsal Excitatory Neurons.* Other names for this target antigen include N-acetylglucosamine-6-sulfatase, arylsulfatase, sulfatase FP, and extracellular sulfatase Sulf-1. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some Sulfatase 1 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.
*HuBMAP Human Reference Atlas v1.4