Anti-SPI1 antibodies are used in the immunodetection of the protein Spi-1 proto-oncogene. In humans, the canonical protein has a reported length of 270 amino acid residues and a mass of 31.1 kDa. Its subcellular localization is in the nucleus. Up to 2 different isoforms have been reported for this protein. It is notably expressed in many tissues, such as the bone marrow and lung. A member of the ETS protein family, SPI1 is known to be involved with the differentiation of certain cell types. The SPI1 marker can be used to identify Myeloid Progenitors (MOP), Early T Lineage Precursor Cells, and Specified Double Negative Thymocytes.* Synonyms for this target antigen include OF, PU.1, SFPI1, SPI-A, transcription factor PU.1, and AGM10. SPI1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4