TRMT61B encodes the human gene, TRNA methyltransferase 61B. It may also be known as: tRNA. The encoded protein is an enzyme with an amino acid length of 477 and a mass of 53.0 kDa. Other isoforms may exist. TRMT61B is a member of the Class I-like SAM-binding methyltransferase superfamily, TRM61 family. Homologs of this gene exist in other organisms, including: Chicken.