Anti-sphingosine kinase 1 antibodies are used for the immunodetection of the protein encoded by the SPHK1 gene. In humans, the canonical protein has a reported length of 384 amino acid residues and a mass of 42.5 kDa. Its subcellular localization is in the cell membrane, nucleus, and cytoplasm. Alternative splicing is reported to yield 3 different isoforms for this protein. It is reported to be widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle. It is known to catalyze the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Other names for this target antigen include SK 1, SPK 1, acetyltransferase SPHK1, and SPHK. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 120 citations in the literature describe the use of sphingosine kinase 1 antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.