Anti-split hand/foot malformation (ectrodactyly) type 1 antibodies are used in antigen-specific immunodetection in biological samples. The target split hand/foot malformation (ectrodactyly) type 1 is a known alias name of the protein SEM1 26S proteasome subunit, encoded by the SEM1 gene in humans. This 70-amino acid residue protein is a known component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. It is localized to the nucleus of the cell. In terms of tissue expression, it is reported to be expressed in limb bud, craniofacial primordia and skin. Other synonyms for split hand/foot malformation (ectrodactyly) type 1 include C7orf76, DSS1, and ECD.