Split hand/foot malformation (ectrodactyly) type 1, or, SHFM1, is a human gene. Other names include: 26S proteasome complex subunit DSS1; Split hand/foot deleted protein 1; Split hand/foot malformation type 1 protein; Deleted in split hand/split foot protein 1; deleted in split-hand/foot 1; DSS1; SEM1; SHFD1; SHSF1; Shfdg1. The encoded protein has an amino acid length of 70 and a mass of 8.3 kDa. Other isoforms may exist. Split hand/foot malformation (ectrodactyly) type 1 is a member of the DSS1/SEM1 family. This gene shares homology with other species, including: Frog, Fly.