Anti-Ribonuclease T2 antibodies are used in the immunodetection of the protein encoded by the RNASET2 gene. In humans, the canonical protein has a reported length of 256 amino acid residues and a mass of 29.5 kDa. Its subcellular localization is in the mitochondria, ER, lysosomes, and is also secreted. Alternative splicing is reported to yield 2 different isoforms for this protein. It is ubiquitously expressed across many tissue types. A member of the RNase T2 protein family, it is a reported ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Post-translational modifications have been described, including glycosylation. Other names for this target antigen include bA514O12.3, ribonuclease 6, and RNASE6PL.