Anti-Interleukin 1 beta antibodies are used for the immunodetection of the protein encoded by the IL1B gene. In humans, the canonical protein has a reported length of 269 amino acid residues and a mass of 30.7 kDa. Its subcellular localization is in the lysosomes, cytoplasm, and is secreted. It is reported to be expressed in activated monocytes/macrophages. A member of the IL-1 protein family, it is known to be involved with the apoptotic pathway and cell to cell signaling. Post-translational modifications have been described, including protein cleavage. The interleukin 1 beta marker can be used to characterize Megakaryocytes-Erythroid-Mast Cells Progenitors (MEMP).* Other names for this target antigen include IL1-BETA, IL1F2, IL1beta, IL-1 beta, catabolin, preinterleukin 1 beta, pro-interleukin-1-beta, and IL-1. Gene orthologs have been identified in the mouse, rat, bovine, zebrafish and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4