Anti-MAP3K8 antibodies are used in the immunodetection of the protein mitogen-activated protein kinase kinase kinase 8. In humans, the canonical protein has a reported length of 467 amino acid residues and a mass of 52.9 kDa. Its subcellular localization is in the cytoplasm. It is reported to be expressed in several normal tissues and human tumor-derived cell lines. A member of the STE Ser/Thr protein kinase protein family, MAP3K8 is known to be required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF-alpha (TNF) during immune responses. Synonyms for this target antigen include AURA2 and COT. MAP3K8 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of MAP3K8 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.