Anti-neurofibromin 1 antibodies are used for the immunodetection of the protein encoded by the NF1 gene. In humans, the canonical protein has a reported length of 2839 amino acid residues and a mass of 319.4 kDa. Its subcellular localization is in the nucleus and cell membrane. Alternative splicing is reported to yield 6 different isoforms for this protein. It is notably expressed in the brain, peripheral nerve, lung, colon and muscle. It is noted to be involved in cytoskeleton organization and angiogenesis. The gene encoding this protein is implicated in Neurofibromatosis. Other names for this target antigen include VRNF, WSS, neurofibromin, neurofibromatosis 1, neurofibromatosis-related protein NF-1, and NFNS. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 60 citations in the literature describe the use of neurofibromin 1 antibodies in research. Immunofluorescence is a widely used application for these antibodies. ELISA, Western Blot, and Immunohistochemistry are also common applications.