Anti-neurobeachin antibodies are used in the immunodetection of the protein encoded by the NBEA gene. In humans, the canonical protein has a reported length of 2946 amino acid residues and a mass of 327.8 kDa. Its subcellular localization is in the membrane and cytoplasm. Alternative splicing is reported to yield 3 different isoforms for this protein. A member of the WD repeat neurobeachin protein family, it is known to bind to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. Other names for this target antigen include LYST2, NEDEGE, lysosomal-trafficking regulator 2, and BCL8B.