Anti-metallothionein 3 antibodies are used for the immunodetection of the protein encoded by the MT3 gene. In humans, the canonical protein has a reported length of 68 amino acid residues and a mass of 6.9 kDa. It is notably expressed in a subset of astrocytes in the normal human brain, but greatly reduced in the Alzheimer disease (AD) brain. A member of the Metallothionein protein superfamily, it is known to bind heavy metals. Other names for this target antigen include GIFB, GRIF, ZnMT3, growth inhibitory factor, metallothionein 3 (growth inhibitory factor (neurotrophic)), and GIF. Gene orthologs have been identified in the mouse, rat, bovine and chimpanzee species. A number of metallothionein 3 antibodies have been mentioned in research publications and have associated citations. Immunohistochemistry is a widely used application for these antibodies. In addition, ELISA is also a common application.