Anti-ITM2B antibodies are used in the immunodetection of the protein integral membrane protein 2B. In humans, the canonical protein has a reported length of 266 amino acid residues and a mass of 30.3 kDa. Its subcellular localization is in the Golgi and cell membrane. Up to 2 different isoforms have been reported for this protein. It is ubiquitously expressed across many tissue types. A member of the ITM2 protein family, ITM2B is reported to play a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Synonyms for this target antigen include BRI, BRI2, BRICD2B, E25B, E3-16, FBD, RDGCA, and ABRI. ITM2B gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some ITM2B antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.