Anti-GPM6A antibodies are used in the immunodetection of the protein glycoprotein M6A. In humans, the canonical protein has a reported length of 278 amino acid residues and a mass of 31.2 kDa. Its subcellular localization is in the cell membrane. Up to 3 different isoforms have been reported for this protein. It is notably expressed in the cerebellum and cerebral cortex. A member of the Myelin proteolipid protein family, GPM6A is known to be involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Post-translational modifications have been described, including N-glycosylation and palmitoylation.
The GPM6A marker can be used to identify Ascending Vasa Recta Endothelial Cells.* Synonyms for this target antigen include M6A, neuronal membrane glycoprotein M6-a, and GPM6. GPM6A gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of GPM6A antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4