Anti-MECP2 antibodies are used in the immunodetection of the protein methyl-CpG binding protein 2. In humans, the canonical protein has a reported length of 486 amino acid residues and a mass of 52.4 kDa. Its subcellular localization is in the nucleus. Up to 2 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. MECP2 is reported to be a chromosomal protein that binds to methylated DNA. Post-translational modifications have been described, including phosphorylation. The MECP2 gene has been associated with the disease, Angelman syndrome. Synonyms for this target antigen include MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, and AUTSX3. MECP2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish and chimpanzee species. Over 310 citations in the literature describe the use of MECP2 antibodies in research. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.