Anti-ISL LIM Homeobox 1 antibodies are used for the immunodetection of the protein encoded by the ISL1 gene. In humans, the canonical protein has a reported length of 349 amino acid residues and a mass of 39 kDa. Its subcellular localization is in the nucleus. It is reported to be expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain. It is noted to be involved in neuronal development and the Wnt signaling pathway. Post-translational modifications have been described, including ubiquitination and phosphorylation.
The ISL LIM homeobox 1 marker can be used to characterize Brain Medium Spiny Neurons, Amygdaloid Complex Medium Spiny Neurons, Brain Splatter Neurons, Hypothalamus Splatter Neurons, and Gray Matter Splatter Neurons.* Other names for this target antigen include insulin gene enhancer protein ISL-1, islet-1, and ISLET1. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 90 citations in the literature describe the use of ISL LIM Homeobox 1 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4