Anti-Glycoprotein M6A antibodies are used for the immunodetection of the protein encoded by the GPM6A gene. In humans, the canonical protein has a reported length of 278 amino acid residues and a mass of 31.2 kDa. Its subcellular localization is in the cell membrane. Alternative splicing is reported to yield 3 different isoforms for this protein. A member of the Myelin proteolipid protein family, it is known to be involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Post-translational modifications have been described, including N-glycosylation and palmitoylation.
The glycoprotein M6A marker can be used to characterize Ascending Vasa Recta Endothelial Cells.* Other names for this target antigen include M6A, neuronal membrane glycoprotein M6-a, and GPM6. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of Glycoprotein M6A antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4