Anti-CD3E antibodies are used in the immunodetection of the protein CD3 epsilon subunit of T-cell receptor complex. In humans, the canonical protein has a reported length of 207 amino acid residues and a mass of 23.1 kDa. Its subcellular localization is in the cell membrane. It is notably expressed in the tonsil, spleen, lymph node, bone marrow, and appendix. CD3E is known to be a part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. Post-translational modifications have been described, including phosphorylation. The CD3E marker can be used to identify CD8+ T Cells, CD4+ T Cells, Mature NK T Cells, Naive Thymus-Derived CD4+ ?ß T Cells, and Effector Memory CD4+ ?ß T Cells.* Synonyms for this target antigen include IMD18, T3E, TCRE, T-cell surface glycoprotein CD3 epsilon chain, CD3-epsilon, and CD3epsilon. CD3E gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4