Anti-Arrestin, beta 1 antibodies are used in the immunodetection of the protein encoded by the ARRB1 gene. In humans, the canonical protein has a reported length of 418 amino acid residues and a mass of 47.1 kDa. Its subcellular localization is in the cell membrane, nucleus, cytoplasmic vesicles, and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Arrestin protein family, it is reported to function in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. Post-translational modifications have been described, including ubiquitination and phosphorylation. Other names for this target antigen include ARR1, beta-arrestin-1, arrestin 2, non-visual arrestin-2, and ARB1.