Anti-FBN1 antibodies are used in the immunodetection of the protein fibrillin 1. In humans, the canonical protein has a reported length of 2871 amino acid residues and a mass of 312.3 kDa. It has been described to be a secreted protein. It is notably expressed in the skin, placenta, ovary, endometrium, and adipose tissue. A member of the Fibrillin protein family, FBN1 is known to be involved with eye development and carbohydrate metabolism and homeostasis. Post-translational modifications have been described, including O-glycosylation and protein cleavage.
The FBN1 marker can be used to identify Type 2 Thymic Fibroblasts.* Synonyms for this target antigen include ECTOL1, FBN, GPHYSD2, MASS, MFLS, MFS1, OCTD, and ACMICD. FBN1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 70 citations in the literature describe the use of FBN1 antibodies in research. Immunohistochemistry is a widely used application for these antibodies. ELISA and Western Blot are also common applications.
*HuBMAP Human Reference Atlas v1.4