Anti-enamelin antibodies are used for the immunodetection of the protein encoded by the ENAM gene. In humans, the canonical protein has a reported length of 1142 amino acid residues and a mass of 128.8 kDa. Its subcellular localization is in the extracellular matrix and is secreted. It is reported to be expressed in tooth particularly in odontoblast, ameloblast and cementoblast. It is reported to be involved in mineralization and structural organization of enamel. Post-translational modifications have been described, including phosphorylation and glycosylation. The gene encoding this protein is implicated in Amelogenesis imperfecta. Other names for this target antigen include AI1C, AIH2, amelogenesis imperfecta 2, hypocalcification (autosomal dominant), and ADAI. Gene orthologs have been identified in the mouse, rat, bovine, frog and chimpanzee species. Western Blot is the most common application for the enamelin antibodies listed below. ELISA, Flow Cytometry, and Immunohistochemistry are also common applications.