Anti-Claudin 16 antibodies are used for the immunodetection of the protein encoded by the CLDN16 gene. In humans, the canonical protein has a reported length of 235 amino acid residues and a mass of 26.1 kDa. Its subcellular localization is in the cell membrane. A member of the Claudin protein family, it is known to play an important role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. The claudin 16 marker can be used to characterize Cortical Thick Ascending Limb Cells.* Other names for this target antigen include PCLN1, hypomagnesemia 3, with hypercalciuria and nephrocalcinosis, paracellin-1, and HOMG3. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species. A number of Claudin 16 antibodies have been mentioned in research publications and have associated citations. Western Blot, Immunofluorescence, and Immunohistochemistry are common applications for these antibodies.
*HuBMAP Human Reference Atlas v1.4