Anti-ANLN antibodies are used in the immunodetection of the protein anillin, actin binding protein. In humans, the canonical protein has a reported length of 1124 amino acid residues and a mass of 124.2 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is ubiquitously expressed across many tissue types. ANLN is known to be required for cytokinesis. Post-translational modifications have been described, including ubiquitination and phosphorylation.
The ANLN marker can be used to identify Brain Oligodendrocytes.* Synonyms for this target antigen include Scraps, scra, anillin, and FSGS8. ANLN gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of ANLN antibodies have been mentioned in research publications and have associated citations. Immunohistochemistry is a widely used application for these antibodies. ELISA, Western Blot, and Immunofluorescence are also common applications.
*HuBMAP Human Reference Atlas v1.4