Anti-ANO2 antibodies are used in the immunodetection of the protein anoctamin 2. In humans, the canonical protein has a reported length of 1003 amino acid residues and a mass of 114 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is notably expressed in the nasopharynx, fallopian tube, and bronchus. It is a member of the Anoctamin protein family. Post-translational modifications have been described, including glycosylation.
The ANO2 marker can be used to identify Cerebral Cortex Neurons.* Synonyms for this target antigen include transmembrane protein 16B (eight membrane-spanning domains), and anoctamin 2, calcium activated chloride channel. ANO2 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. A number of ANO2 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4