Anti-HPD antibodies are used in the immunodetection of the protein 4-hydroxyphenylpyruvate dioxygenase. In humans, the canonical protein has a reported length of 393 amino acid residues and a mass of 44.9 kDa. Its subcellular localization is in the membrane, ER, Golgi, and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is notably expressed in the kidney and liver. A member of the 4HPPD protein family, HPD is known to catalyze the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.
The HPD marker can be used to identify Choroid Plexus Non-Neuronal Cells.* Synonyms for this target antigen include 4HPPD, GLOD3, HPPDASE, PPD, 4-hydroxyphenylpyruvic acid oxidase, glyoxalase domain containing 3, and 4-HPPD. HPD gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. A number of HPD antibodies have been mentioned in research publications and have associated citations. ELISA, Western Blot, Immunofluorescence, and Immunohistochemistry are common applications for these antibodies.
*HuBMAP Human Reference Atlas v1.4