Anti-SMS antibodies are used in the immunodetection of the protein spermine synthase. In humans, the canonical protein has a reported length of 366 amino acid residues and a mass of 41.3 kDa. Up to 2 different isoforms have been reported for this protein. It is notably expressed in many tissues, such as the ovary and testis. A member of the Spermidine/spermine synthase protein family, Sms is known to catalyze the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). The SMS gene has been associated with the disease, Intellectual developmental disorder. Synonyms for this target antigen include MRXSSR, SPMSY, SRS, SpS, spermidine aminopropyltransferase, and MRSR. SMS gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of Sms antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. Flow Cytometry, Immunofluorescence, and Immunohistochemistry are also common applications.