Anti-ZIC1 antibodies are used in the immunodetection of the protein Zic family member 1. In humans, the canonical protein has a reported length of 447 amino acid residues and a mass of 48.3 kDa. Its subcellular localization is in the nucleus and cytoplasm. It is notably expressed in the hippocampus, cerebral cortex, cerebellum, and caudate. A member of the GLI C2H2-type zinc-finger protein family, ZIC1 is known to act as a transcriptional activator.
The ZIC1 marker can be used to identify Brain Splatter Neurons and Gray Matter Splatter Neurons.* Synonyms for this target antigen include CRS6, ZIC, ZNF201, zinc finger protein ZIC 1, Zic family member 1 (odd-paired homolog, Drosophila), and BAIDCS. ZIC1 gene orthologs have been reported in the mouse, rat, bovine, zebrafish, chimpanzee and chicken species. A number of ZIC1 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4