HSD17B1 encodes the human gene, Hydroxysteroid (17-beta) dehydrogenase 1. It may also be known as: Estradiol 17-beta-dehydrogenase 1; 17-beta-hydroxysteroid dehydrogenase type 1; 17-beta-HSD 1; Placental 17-beta-hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 28C member 1; Estradiol 17-beta-dehydrogenase 1 ; Estradiol 17-beta-dehydrogenase-1; short chain dehydrogenase/reductase family 28CE, member 1; EDH17B2; SDR28C1. The encoded protein is an enzyme with an amino acid length of 328 and a mass of 35.0 kDa. Other isoforms may exist. HSD17B1 is a member of the Short-chain dehydrogenases/reductases (SDR) family. Homologs of this gene exist in other organisms, including: Mouse.