Anti-CFH antibodies are used in the immunodetection of the protein complement factor H. In humans, the canonical protein has a reported length of 1231 amino acid residues and a mass of 139.1 kDa. It has been described to be a secreted protein. Up to 2 different isoforms have been reported for this protein. It is reported to be expressed in the retinal pigment epithelium. CFH is a reported glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Post-translational modifications have been described, including sulfation and glycosylation. The CFH marker can be used to identify Parietal Epithelial Cells.* Synonyms for this target antigen include AMBP1, ARMD4, ARMS1, CFHL3, FH, FHL1, HF, and AHUS1. CFH gene orthologs have been reported in the mouse, bovine, frog, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4