Anti-TRIM5 antibodies are used in the immunodetection of the protein tripartite motif containing 5. In humans, the canonical protein has a reported length of 493 amino acid residues and a mass of 56.3 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 6 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the TRIM/RBCC protein family, TRIM5 is known to be involved with autophagy pathways and viral immune response. Post-translational modifications have been described, including ubiquitination. Synonyms for this target antigen include RING-type E3 ubiquitin transferase TRIM5, ring finger protein 88, tripartite motif protein TRIM5, tripartite motif-containing protein 5 alpha, and tripartite motif-containing protein 5. A number of TRIM5 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.