Anti-NPSR1 antibodies are used in the immunodetection of the protein neuropeptide S receptor 1. In humans, the canonical protein has a reported length of 371 amino acid residues and a mass of 42.7 kDa. Its subcellular localization is in the cell membrane and cytoplasm. Up to 9 different isoforms have been reported for this protein. A member of the G-protein coupled receptor 1 protein family, NPSR1 is known to be involved with the regulation of the ERK1 and ERK2 signaling cascade. Post-translational modifications have been described, including glycosylation.
The NPSR1 marker can be used to identify Deep-Layer Near-Projecting Neurons, Midbrain Splatter Neurons, and Midbrain-Derived Inhibitory Neurons.* Synonyms for this target antigen include G-protein coupled receptor 154, G-protein coupled receptor PGR14, G-protein coupled receptor for asthma susceptibility, vasopressin receptor-related receptor 1, and neuropeptide S receptor. NPSR1 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Some NPSR1 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4