Anti-GNGT1 antibodies are used in the immunodetection of the protein G protein subunit gamma transducin 1. In humans, the canonical protein has a reported length of 74 amino acid residues and a mass of 8.5 kDa. Its subcellular localization is in the cell membrane. It is notably expressed in the retina. A member of the G protein gamma protein family, GNGT1 is known to be involved with the apoptotic pathway and the cellular response to hypoxia.
The GNGT1 marker can be used to identify Eye Photoreceptor Cells.* Synonyms for this target antigen include HG3G1, guanine nucleotide-binding protein G(T) subunit gamma-T1, guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1, and GNG1. GNGT1 gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species. Some GNGT1 antibodies may have been used in research and have associated citations. Immunofluorescence is a widely used application for these antibodies. ELISA, Western Blot, and Immunocytochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4