Anti-DSC2 antibodies are used in the immunodetection of the protein desmocollin 2. In humans, the canonical protein has a reported length of 901 amino acid residues and a mass of 100 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is reported to be expressed in the heart. DSC2 is known to be a component of intercellular desmosome junctions. Post-translational modifications have been described, including glycosylation. The DSC2 marker can be used to identify Fibroblastic Reticular Cells (FRC).* Synonyms for this target antigen include CDHF2, DG2, DGII/III, DSC3, cadherin family member 2, desmosomal glycoprotein II/III, and ARVD11. DSC2 gene orthologs have been reported in the mouse, bovine and chimpanzee species. A number of DSC2 antibodies have been mentioned in research publications and have associated citations. ELISA, Western Blot, and Immunohistochemistry are common applications for these antibodies.
*HuBMAP Human Reference Atlas v1.4