Anti-CRBN antibodies are used in the immunodetection of the protein cereblon. In humans, the canonical protein has a reported length of 442 amino acid residues and a mass of 50.5 kDa. Its subcellular localization is in the membrane, nucleus, and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is widely expressed across many tissue types. A member of the CRBN protein family, CRBN is reported to be a substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 or ILF2. Post-translational modifications have been described, including ubiquitination. Synonyms for this target antigen include MRT2A, protein cereblon, protein x 0001, and MRT2. CRBN gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 70 citations in the literature describe the use of CRBN antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.