Anti-sphingosine kinase 2 antibodies are used for the immunodetection of the protein encoded by the SPHK2 gene. In humans, the canonical protein has a reported length of 654 amino acid residues and a mass of 69.2 kDa. Its subcellular localization is in the nucleus, mitochondria, ER, and cytoplasm. Alternative splicing is reported to yield 5 different isoforms for this protein. It is reported to be mainly expressed in adult kidney, liver, and brain. It is known to catalyze the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Post-translational modifications have been described, including protein cleavage and phosphorylation. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish and chimpanzee species. Over 70 citations in the literature describe the use of sphingosine kinase 2 antibodies in research. ELISA, Western Blot, and Immunohistochemistry are common applications for these antibodies.