Anti-RNF216 antibodies are used in the immunodetection of the protein ring finger protein 216. In humans, the canonical protein has a reported length of 866 amino acid residues and a mass of 99.4 kDa. Its subcellular localization is in the cytoplasm. Alternative splicing is reported to yield 3 different isoforms for this protein. It is found to be widely expressed, with the highest levels of expression in testis and peripheral blood leukocytes. Among its functions, RNF216 is involved with the apoptotic pathway. Post-translational modifications have been described, including ubiquitination. Synonyms for this target antigen include TRIAD3, U7I1, UBCE7IP1, ZIN, E3 ubiquitin-protein ligase RNF216, and CAHH.