Anti-PRKCA antibodies are used in the immunodetection of the protein protein kinase C alpha. In humans, the canonical protein has a reported length of 672 amino acid residues and a mass of 76.8 kDa. Its subcellular localization is in the cell membrane, nucleus, mitochondria, and cytoplasm. It is notably expressed in many tissues, such as the adrenal gland and cerebellum. A member of the AGC Ser/Thr protein kinase protein family, PRKCA is known to be involved with angiogenesis and the apoptotic pathway.
The PRKCA marker can be used to identify Retinal Bipolar Neuron.* Synonyms for this target antigen include PKC-alpha, PKCA, PKCI+/-, PKCalpha, PRKACA, protein kinase C alpha type, PKC-A, and AAG6. PRKCA gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 1400 citations in the literature describe the use of PRKCA antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4