Anti-PAX5 antibodies are used in the immunodetection of the protein paired box 5. In humans, the canonical protein has a reported length of 391 amino acid residues and a mass of 42.1 kDa. Its subcellular localization is in the nucleus. Up to 11 different isoforms have been reported for this protein. It is notably expressed in the tonsil, spleen, lymph node, bone marrow, and appendix. PAX5 is reported to be a transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage.
The PAX5 marker can be used to identify Immature B Cells, Naive B Cells, Precursor B Cells, and Brain Splatter Neurons.* Synonyms for this target antigen include BSAP, paired box protein Pax-5, B-cell lineage specific activator, paired box homeotic gene 5, paired domain gene 5, and ALL3. PAX5 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 130 citations in the literature describe the use of PAX5 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4