Anti-NCR1 antibodies are used in the immunodetection of the protein natural cytotoxicity triggering receptor 1. In humans, the canonical protein has a reported length of 304 amino acid residues and a mass of 34.5 kDa. Its subcellular localization is in the cell membrane. Up to 6 different isoforms have been reported for this protein. A member of the Natural cytotoxicity receptor (NCR) protein family, NCR1 is reported to be a cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Post-translational modifications have been described, including O-glycosylation and N-glycosylation. The NCR1 marker can be used to identify Natural Killer Cells.* Synonyms for this target antigen include LY94, NK-p46, NKP46, NK cell-activating receptor, lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46), and CD335. NCR1 gene orthologs have been reported in the mouse, rat and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4